Low-order non-spatial effects dominate second-order spatial effects in the texture quantifier analysis of 18F-FDG-PET images.
BackgroundThere is increasing interest in applying image texture quantifiers to assess the intra-tumor heterogeneity observed in FDG-PET images of various cancers.Use of these quantifiers as prognostic indicators of disease outcome and/or treatment response has yielded inconsistent results.We study the general applicability of some well-established